28 September Seminars

09:30 - 10:00

Microfluidics in the Pharmaceutical Field

Speaker

09:30 - 09:50

STYL’One Compaction Simulators : from Excipients/API Characterization to Scale-up Support

Compaction simulators offer the capability to replicate tablet compression parameters at production scale right from the development steps - using minimal material quantities. This presentation will focus on the fundamentals of compaction simulator design and will present several case studies around material characterization, formulation development, scale-up and troubleshooting of tablet defects. It will highlight the correlation between tablet properties produced on a compaction simulator and tablets manufactured on a high-speed production press, for single layer, multilayer and tab-in-tab application.

Speaker

09:50 - 10:10

Harnessing Raman Imaging to Boost Pharmaceutical Product Analysis, From Formulation to QC

Drug development is a long road with many dead ends to avoid. Part of the journey involves understanding the spatial distribution of active pharmaceutical ingredients (APIs) and excipients, investigating final product homogeneity and differentiating chemically similar molecules such as polymorphs, to guarantee product quality and to maximise process efficiency.
To ensure that the correct route it taken, it is critical that engineers and researchers have the best possible instrumentation. Enter Raman imaging microscopy.
This talk outlines how Raman imaging can assist throughout the development and production process, from drug discovery to product formulation and will also touch on post-marketed investigation.

Speaker

  • Adam Holland Senior Raman and µPL Product Manager - HORIBA UK Ltd
10:00 - 10:30

Academy of Pharmaceutical Sciences – Smart Nanotherapeutics for Pancreatic Cancer Therapy

Speaker

10:00 - 10:30

Smart Nanotherapeutics for Pancreatic Cancer Therapy

Speaker

10:10 - 10:30

Digitalization of Particle Monitoring in the Cleanroom to Enhance your Contamination Control Strategy

How do you upgrade your manual particle counting environmental monitoring program to reduce risk of transcript errors, reduce time consuming paper trails, reduce labor and to automate your cleanroom monitoring so your data integrity is intact and meets 21CFR11 compliance?

Speaker

10:30 - 11:30

Break & Exhibition

11:00 - 11:20

Nutritional Solutions to Support Cancer Treatment

Speaker

11:00 - 11:20

PMTC Approach to Understanding the Pharmaceutical Cleaning Process

Pharmaceutical cleaning and subsequent verification and validation have always been time consuming and a costly operation in multipurpose pharmaceutical plants. It has a significant impact on plant efficiency, utilities and resources. About 50% of time is spent doing cleaning, resulting in a massive impact on downtime, costs and changeovers. This presentation will cover the PMTC approach towards understanding the cleaning process in order to develop efficacious cleaning procedures and robust verification methods. It will also cover the benefit of the use of PAT tools for real time monitoring and verification of cleaning to reduce the cleaning times, costs and wastes and to develop more sustainable processes. The methodology is based on computational and experimental methodologies to optimise the cleaning processes and offers a deep understanding of the mechanisms by which the residues are removed. The implementation of the method in industrial setting helped the centre achieving very impactful outcomes by reducing the changeovers by ~10% /year, solvent usage by ~40% and changeover times by an average of two weeks.

Speaker

11:20 - 11:40

Computational Studies of Surface Cleaning by Flowing Solvents

This presentation will show how computational fluid dynamics studies can be applied to determine the cleaning rates of vessels used for pharmaceutical production. During changeover between batches of different products, vessels are often cleaned with solvent sprays. To reduce solvent and energy use and transition to greener solvents, there is a need to understand the rates at which surfaces are cleaned by flows of pure solvents and mixtures. Simulations of film flows will be presented and compared with experimental findings. Computational predictions of solvent distribution and cleaning rates could be used to optimise the selection of cleaning agents and methods.

Speaker

  • Dr Orest Shardt Lecturer in the School of Engineering - University of Limerick
11:20 - 11:40

Improving Palatability Oral Dosage Form

One of the major huddles in formulation is to improve the palatability of oral dosage forms, especially now when we are developing medicines for paediatrics and geriatric populations. Palatability is one pharmaceutical attribute of dosage forms which affect patient's acceptability of an oral medicinal product and it is crucial for compliance to their treatment. The non-acceptance of a medicine due to the bad taste can have detrimental consequences on the treatment outcome if the medicine is partially or not taken, leading to suboptimal therapeutic effect to no effect at all. In this presentation we will discuss how we can improve the palatability of oral dosage forms.

Speaker

  • Shilpa Mistry Head of Pharma, UK and Ireland - Chemlink Specialities Ltd
11:40 - 12:00

Application of Digital Tools and New Excipients to Develop Formulations Faster

This presentation will be an interactive example of how the use of BASF ZoomLab and new Kollitab DC87L can be used to reduce development time and material usage for the formulation of APIs. ZoomLab is a, free, on-line tool that can be used to predict formulations for tabeletting based on the certain parameters. Kollitab DC87L is a co-processed excipient designed for direct compression. Attendees can select the API they wish to see formulated on the booth and the API with most votes will be formulated live, via webex, at the BASF lab in Germany.

Speaker

11:40 - 12:00

Application of Visible Residue Limits in Cleaning Validation

Speaker

  • Dr Conor Collins Head of Validation / Product Lifecycle Management for Pharma Supply - GSK
12:00 - 14:30

Break & Exhibition

14:00 - 14:30

GMP Certification Scheme and Certification Body Qualification Guide 

Speaker

14:00 - 14:20

SSPC _4

14:20 - 14:40

SSPC _5

14:30 - 15:00

Sustainability – What Does It Mean or Excipient Makers and Users?

Speaker

14:40 - 15:00

SSPC _6