Synopsis

Compaction simulators offer the capability to replicate tablet compression parameters at production scale right from the development steps – using minimal material quantities. This presentation will focus on the fundamentals of compaction simulator design and will present several case studies around material characterization, formulation development, scale-up and troubleshooting of tablet defects. It will highlight the correlation between tablet properties produced on a compaction simulator and tablets manufactured on a high-speed production press, for single layer, multilayer and tab-in-tab application.